1,534 research outputs found

    Navigating Into the New Safe Harbor : Model Interest Surveys as a New Tool for Title IX Compliance Programs

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    The policy debate and the divergent views expressed in the mainstream media have provided little practical advice regarding the Additional Clarification or the Model Survey to the well-intentioned academic institution seeking to comply with Title IX in a cost-effective manner. This Article is intended to be a source of such practical advice. This Article discusses the Additional Clarification from the perspective of the academic institution and seeks to help it evaluate whether to implement the OCR\u27s recommendations, including the Model Survey, as part of its Title IX compliance program. The Article does not engage in the policy debate regarding the Additional Clarification or Title IX enforcement policy generally. Section I of this Article discusses Prong Three from a historical perspective, to place the Additional Clarification in context. Section II summarizes the contributions of the Additional Clarification to the Title IX compliance landscape and explains the OCR\u27s recommendations for using the Model Survey. Section III discusses possible advantages and disadvantages of using the Model Survey. Section IV suggests an approach to using the Model Survey as an ongoing component of a Title IX compliance monitoring program

    Enhancement of latent fingerprints on fabric using the cyanoacrylate fuming method followed by infrared spectral mapping

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    A method has been developed for the visualization of latent fingerprints on fabrics, which is based upon cyanoacrylate (superglue) fuming followed by imaging using an infrared microscope. Results show that imaging on smooth, shiny fabrics such as polyester, silk, nylon and acetate of different colors and patterns can give an improvement over existing enhancement methods. Results for cotton and polycotton were less successful and it is thought this may be due a combination of the presence of the carbonyl functional group in these fabrics as well as their absorbency to fingerprint sweat. The carbonyl peak (1700 cm-1) provided the optimum spectroscopic feature to map and image a fingerprint. Comparisons between infrared mapping at a specific frequency range and principal component analysis showed that improved imaging was obtained with principal component analysis

    Enhancement of aged and denatured fingerprints using the cyanoacrylate fuming technique following dusting with amino acid-containing powders

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    We have carried out experiments to investigate the ageing of latent fingerprints deposited on black PVC over a period of 4-15 weeks. A thumbprint was used in each case and before deposition of the print the donor rubbed their thumb around their nose to add sebaceous deposits. We have studied the effect of heat, light and moisture and we find that moisture is the most significant factor in the degradation of the latent print. We have attempted to enhance these latent prints by dusting with valine powder or powders composed of valine mixed with gold or red fluorescent commercial fingerprint powders. In order to make a direct comparison between “treated” and “untreated” prints, the prints were cut in half with one half being “treated” and one not. Our studies show the best results being obtained when powders of valine and red fluorescent powders are applied prior to cyanoacrylate fuming

    Sediment disturbance by Ediacaran bulldozers and the roots of the Cambrian explosion

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    Se han documentado fósiles de rastros de excavadoras de sedimentos en los estratos ediacaranos terminales del Grupo Nama en Namibia, donde se encuentran en el miembro Spitskop de la Formación Urusis (subgrupo Schwarzrand). Consisten en fósiles de trazas unilobadas a bilobadas horizontales a subhorizontales que describen garabatos, círculos y, más raramente, espirales y meandros abiertos, y que muestran una estructura interna indicativa de relleno activo. Su presencia sugiere que la explotación del ecoespacio infaunal poco profundo por parte de bilateros relativamente grandes ya estaba en marcha en los albores del Fanerozoico. El excavado eficiente sugiere que el desarrollo de la espina dorsal está muy probablemente relacionado con el aumento del tamaño del cuerpo de los metazoos. Estos fósiles en trazas son los primeros representantes claros hasta ahora registrados del arrastre de sedimentos, actividad que puede haber tenido un impacto negativo en las comunidades de alimentación en suspensión y/o de osmotrofos, así como en las esteras, lo que representa los primeros ejemplos de ingeniería de ecosistemas y amensalismo de grupos tróficos. La aparición de bulldozers de sedimentos puede haber promovido el establecimiento de gradientes en la distribución horizontal y vertical de material orgánico en relación con entornos espacialmente heterogéneos en el fondo marino en un momento crítico de la evolución de la Tierra.Trace fossils of sediment bulldozers are documented from terminal Ediacaran strata of the Nama Group in Namibia, where they occur in the Spitskop Member of the Urusis Formation (Schwarzrand Subgroup). They consist of unilobate to bilobate horizontal to subhorizontal trace fossils describing scribbles, circles and, more rarely, open spirals and meanders, and displaying an internal structure indicative of active fill. Their presence suggests that exploitation of the shallow infaunal ecospace by relatively large bilaterians was already well underway at the dawn of the Phanerozoic. Efficient burrowing suggests coelom development most likely linked to metazoan body-size increase. These trace fossils are the earliest clear representatives so far recorded of sediment bulldozing, an activity that may have had a negative impact on suspension-feeding and/or osmotroph communities, as well as on matgrounds, representing early examples of ecosystem engineering and trophic-group amensalism. The occurrence of sediment bulldozers may have promoted the establishment of gradients in horizontal and vertical distribution of organic material in connection with spatially heterogeneous environments on the sea floor at a critical time in Earth evolution.• Natural Sciences and Engineering Research Council (NSERC) Discovery. Grants 311726-05/13 y 311727-05/15, para Louis Alberto Buatois y Maria Gabriela Mángano • Palaeontological Scientific Trust (Sudáfrica). Ayuda a John Almond • Ministerio de Ciencia e Innovación y Fondo Europeo de Desarrollo Regional (FEDER). Subvención CGL-2012-37237, para Sören JensenpeerReviewe

    Patient-Specific Prosthetic Fingers by Remote Collaboration - A Case Study

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    The concealment of amputation through prosthesis usage can shield an amputee from social stigma and help improve the emotional healing process especially at the early stages of hand or finger loss. However, the traditional techniques in prosthesis fabrication defy this as the patients need numerous visits to the clinics for measurements, fitting and follow-ups. This paper presents a method for constructing a prosthetic finger through online collaboration with the designer. The main input from the amputee comes from the Computer Tomography (CT) data in the region of the affected and the non-affected fingers. These data are sent over the internet and the prosthesis is constructed using visualization, computer-aided design and manufacturing tools. The finished product is then shipped to the patient. A case study with a single patient having an amputated ring finger at the proximal interphalangeal joint shows that the proposed method has a potential to address the patient's psychosocial concerns and minimize the exposure of the finger loss to the public.Comment: Open Access articl

    Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

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    Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances in understanding ALS disease mechanisms has come from the identification of pathogenic mutations in dominantly inherited familial ALS (FALS). We previously reported a coding mutation in D-amino acid oxidase (DAOR199W) associated with FALS. DAO metabolises D-serine, an essential co-agonist at the N-Methyl-D-aspartic acid glutamate receptor subtype (NMDAR). Using primary motor neuron cultures or motor neuron cell lines we demonstrated that expression of DAOR199W, promoted the formation of ubiquitinated protein aggregates, activated autophagy and increased apoptosis. The aim of this study was to characterise the effects of DAOR199W in vivo, using transgenic mice overexpressing DAOR199W. Marked abnormal motor features, e.g. kyphosis, were evident in mice expressing DAOR199W, which were associated with a significant loss (19%) of lumbar spinal cord motor neurons, analysed at 14 months. When separated by gender, this effect was greater in females (26%; p< 0.0132). In addition, we crossed the DAOR199W transgenic mouse line with the SOD1G93A mouse model of ALS to determine whether the effects of SOD1G93A were potentiated in the double transgenic line (DAOR199W/SOD1G93A). Although overall survival was not affected, onset of neurological signs was significantly earlier in female double transgenic animals than their female SOD1G93A littermates (125 days vs 131 days, P = 0.0239). In summary, some significant in vivo effects of DAOR199W on motor neuron function (i.e. kyphosis and loss of motor neurons) were detected which were most marked in females and could contribute to the earlier onset of neurological signs in double transgenic females compared to SOD1G93A littermates, highlighting the importance of recognizing gender effects present in animal models of ALS

    What explains the North–South divide in Italian tax compliance? An experimental analysis

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    This is the author accepted manuscript. The final version is available from Palgrave Macmillan via the DOI in this recordI undertake a comparative study assessing the North–South divide in Italian tax compliance, employing the largest behavioral tax compliance experiment to date. Contrary to a large body of literature, I argue that willingness to pay taxes is constructed within a specific institutional environment and reflects the country’s quality of institutions. To test this hypothesis, I use controlled tax compliance experiments from four laboratories in Capua, Rome, Bologna, and Milan. By employing the experimental method, I am able to hold institutions constant allowing me to isolate cultural variation. Contrary to cultural explanations for tax compliance, when controlling the institutional environment, there is no difference in tax compliance. Furthermore, using social value orientation to compare prosociality, I also find no differences between the two regions. I therefore conclude that individuals’ relationship to their states shapes these behavioral differences in tax compliance.Funds for this research were provided by the European Research Council (Grant Agreement No. 295675 )
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